Engineered Immune Organoids and Lymphatics-on-chip

We are interested in developing ex vivo models of the immune system that recapitulate zones of lymph nodes and lymphatics. We have developed an ex vivo B cell follicle, a three-dimensional tissue that is capable of undergoing germinal center reaction to make antibodies in a dish. In another innovation, we have developed on-chip microfluidic devices that recapitulate lymphatic fluid characteristics and demonstrate their effect on tumors that originateĀ in lymph node.