10/12/2017 Huge congrats to the team! Prof. Singh’s co-senior author paper with prof. Ari Melnick at WCMC in Nature Communications models complex immunobiology of genetically engineered double knockout mouse models in organoids and explains how epigenetics of B cells regulates rapid proliferation of germinal center B cells via silencing of a checkpoint gene. Solves a mystery about why and how B cells respond quickly to infectious threats and identifies functioning of an epigenetic switche that may be responsible for lymphomas.
Cornell Story: Why immune cells fire up so rapidly?
Paper (Free access): EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
Nature Communications paper in immune cell epigenetics is out!